Antiproliferative activity from five Myrtaceae essential oils

The Myrtaceae plants are cultivated for their edible fruits and folk medicinal uses. Likewise, leaves, flowers, fruit essential oils (EOs) described to have antiproliferative, antimicrobial, antioxidant activities. This work analyzed the chemical compositions evaluated antiproliferative activities of (EO) Myrcia bella Cambess, fallax (Rich.) DC., guianensis (Aubl.) Eugenia aurata O. Berg, punicifolia (Kunth) DC, from Brazilian Cerrado. EOs were obtained by leaf hydrodistillation Gas Chromatography-Mass Spectrometry (GC-MS) plus Chromatography-Flame Ionization Detector (GC-FID). major component in M. was α-cadinol (14.4%); guaiol acetate M.guianensis, (E)-iso-g‑bisabolene (17.5%). For E. punicifolia, bicyclogermacrene (25.3%) (E)-caryophyllene (18%), respectively, most relevant constituents. tested against human tumor cell lines UACC-62 (melanoma), MCF7 (breast), 786-0 (kidney), NCI-H460 (lung), OVCAR-3 (ovarian), HT29 (colon), K562 (leukemia) one non-tumor line (VERO). presented promising effect (TGI = 1.5 mg/mL), 5.0 no toxicity VERO cells (TGI> 250 mg/mL). other EOs, moderate activity observed. So, conclusion, revealed a good potential anticancer applications.